Virion assembly

Across TCGA cell cohorts, RNA activity of the Virion assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFPQ, RNF138, and HDHD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFPQ grouped by Virion assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SFPQ →	-0.499	-0.295	.009	<.001	3	5
OVARY	RNF138 →	-1.007	-0.272	.003	.006	3	5
CNS	HDHD2 →	-0.598	-0.252	<.001	<.001	3	5
PANCREAS	SLC37A1 →	+1.644	+0.217	.001	.004	3	5
PANCREAS	UNC13D →	+2.591	+0.270	.004	.001	3	5
LARGE_INTESTINE	SH3TC2 →	+1.527	+0.322	.003	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFPQ by Virion assembly activity — PANCREAS

Explore this box plot interactively →