Virion assembly

Across TCGA cell cohorts, RNA activity of the Virion assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL23, COA3, and TMEM97, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Virion assembly activity versus METTL23 in SKIN (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	METTL23 →	+0.571	+0.157	<.001	.006	3	5
BREAST	COA3 →	+0.775	+0.277	<.001	.009	2	5
SKIN	TMEM97 →	+0.775	+0.216	.005	.001	3	4
SKIN	AP3D1 →	+0.590	+0.162	.001	.004	3	4
PANCREAS	QTRT2 →	+0.634	+0.226	.002	.001	3	4
LUNG_SCLC	CXXC1 →	+0.568	+0.153	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019068 vs METTL23 — SKIN

Explore this scatter interactively →