Receptor-mediated endocytosis of virus by host cell

Across TCGA patient cohorts, RNA activity of the Receptor-mediated endocytosis of virus by host cell pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD300LF, PARP15, and COL6A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated endocytosis of virus by host cell activity versus CD300LF in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD300LF →	+0.904	+0.146	<.001	.003	3	5
LUAD	PARP15 →	+0.694	+0.158	<.001	<.001	3	5
BRCA	COL6A1 →	+0.930	+0.417	.001	<.001	3	5
BRCA	MS4A4E →	+0.578	+0.417	<.001	<.001	3	5
LSCC	NRARP →	-1.082	-0.206	<.001	<.001	3	5
LSCC	NFATC2 →	+0.601	+0.153	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019065 vs CD300LF — UCEC

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