Receptor-mediated endocytosis of virus by host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated endocytosis of virus by host cell pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCZ, RALGPS2, and LGSN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCZ grouped by Receptor-mediated endocytosis of virus by host cell-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRKCZ →	-0.213	-0.183	.005	.009	3	6
LUNG_SCLC	RALGPS2 →	-0.329	-0.234	.007	.002	3	6
LIVER	LGSN →	+0.320	+0.197	<.001	.007	3	6
BLOOD_Myeloma	DDHD2 →	-0.377	-0.181	.001	.003	3	5
SOFT_TISSUE	FERMT2 →	+0.212	+0.210	.002	.001	3	5
BREAST	RAC1 →	+0.446	+0.239	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCZ by Receptor-mediated endocytosis of virus by host cell activity — BREAST

Explore this box plot interactively →