Receptor-mediated endocytosis of virus by host cell

Across TCGA cell cohorts, RNA activity of the Receptor-mediated endocytosis of virus by host cell pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV2, CAV1, and CTSL, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated endocytosis of virus by host cell activity versus CAV2 in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CAV2 →	+4.780	+0.250	<.001	<.001	3	15
LIVER	CAV1 →	+4.910	+0.241	<.001	<.001	3	15
STOMACH	CTSL →	+3.692	+0.229	<.001	<.001	3	13
LUNG_SCLC	EPB41 →	-2.022	-0.261	<.001	<.001	3	13
BREAST	FOSL1 →	+3.347	+0.247	<.001	<.001	3	13
LUNG_NSCLC_LUSC	CAVIN1 →	+5.108	+0.320	<.001	<.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019065 vs CAV2 — STOMACH

Explore this scatter interactively →