Phenol-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNL3, CHERP, and HCFC1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound metabolic process activity versus GNL3 in COAD (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GNL3 →	-0.257	-0.018	.002	.001	3	8
BRCA	CHERP →	-0.206	-0.017	<.001	<.001	3	8
GBM	HCFC1 →	-0.214	-0.036	<.001	<.001	3	8
UCEC	WDR43_S77 →	-0.493	-0.029	.003	.003	2	9
LSCC	ZNF638_S1401 →	-0.500	-0.026	<.001	.003	3	8
BRCA	HNRNPC →	-0.255	-0.023	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018958 vs GNL3 — COAD

Explore this scatter interactively →