Phenol-containing compound metabolic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIMREG, STOM, and C20orf194, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound metabolic process activity versus PIMREG in BRCA (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PIMREG →	-0.737	-0.224	.001	.004	3	4
GBM	STOM →	+0.749	+0.830	<.001	<.001	3	4
COAD	C20orf194 →	+0.352	+0.097	.004	.007	3	4
GBM	MSH6 →	-0.443	-0.518	<.001	.001	3	4
COAD	PAICS →	-0.489	-0.152	<.001	.001	3	4
GBM	ARL11 →	+0.531	+0.802	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018958 vs PIMREG — BRCA

Explore this scatter interactively →