Peptidyl-lysine acetylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CBX1, GATAD2B, and HCFC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine acetylation activity versus CBX1 in LUAD (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CBX1 →	+0.263	+0.035	<.001	.001	3	7
LSCC	GATAD2B →	+0.317	+0.048	<.001	<.001	3	7
HNSC	HCFC1 →	+0.203	+0.045	<.001	.005	3	7
LSCC	SMC1A →	+0.192	+0.037	.007	<.001	3	7
HNSC	SPIN1 →	+0.259	+0.060	<.001	<.001	3	7
GBM	HDAC2 →	+0.293	+0.031	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018394 vs CBX1 — LUAD

Explore this scatter interactively →