Peptidyl-lysine acetylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine acetylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5A, COG2, and TMEM81, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB5A grouped by Peptidyl-lysine acetylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CYB5A →	+1.096	+0.738	.006	.005	2	5
STOMACH	COG2 →	+0.576	+0.798	<.001	.001	3	3
STOMACH	TMEM81 →	+0.548	+1.029	.001	.001	3	3
OVARY	RTL8C →	-0.680	-0.963	.002	.003	3	3
OVARY	ZEB1 →	-2.373	-1.029	<.001	.009	2	4
OVARY	ZHX3 →	-1.076	-1.132	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB5A by Peptidyl-lysine acetylation activity — BREAST

Explore this box plot interactively →