Peptidyl-lysine acetylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine acetylation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM222, AKR7L, and ANKMY1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine acetylation activity versus TMEM222 in SKIN (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM222 →	-0.485	-0.233	.001	.001	3	3
SKIN	AKR7L →	-0.407	-0.206	.002	.006	3	3
BLOOD_Myeloma	ANKMY1 →	-1.008	-0.347	.003	.003	3	3
KIDNEY	PPP1R21 →	+0.994	+0.280	.007	.008	2	4
BLOOD_Lymphoma	LRRC47 →	-0.554	-0.176	.005	<.001	3	3
BLOOD_Lymphoma	SLC39A8 →	-1.508	-0.273	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018394 vs TMEM222 — SKIN

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