Protein palmitoylation

Across TCGA patient cohorts, RNA activity of the Protein palmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, PTGIS, and LMOD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein palmitoylation activity versus C7 in UCEC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C7 →	-1.862	-0.528	<.001	.007	2	7
HNSC	PTGIS →	-1.562	-0.771	<.001	<.001	3	6
CCRCC	LMOD1 →	-0.840	-0.174	.004	.001	3	6
OV	ADH1B →	-1.837	-0.632	<.001	<.001	3	5
HNSC	ANK2 →	-0.732	-0.428	<.001	.002	3	5
LSCC	AOC3 →	-0.857	-0.560	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018345 vs C7 — UCEC

Explore this scatter interactively →