Protein geranylgeranylation

Across TCGA patient cohorts, RNA activity of the Protein geranylgeranylation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDRT15P1, FLYWCH1, and SPRN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein geranylgeranylation activity versus CDRT15P1 in LUAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDRT15P1 →	-0.420	-0.148	.001	.001	3	3
LUAD	FLYWCH1 →	-0.309	-0.141	<.001	.001	3	3
LSCC	SPRN →	-0.270	-0.108	.009	.004	3	3
LSCC	GALT →	-0.345	-0.138	.004	<.001	3	3
UCEC	ATF7IP2 →	-0.810	-0.147	<.001	.001	3	3
PDAC	F10 →	-0.537	-0.123	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018344 vs CDRT15P1 — LUAD

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