Protein geranylgeranylation

Across TCGA cell cohorts, RNA activity of the Protein geranylgeranylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF3, ARHGEF6, and THOC6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein geranylgeranylation activity versus PHF3 in OVARY (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PHF3 →	+0.924	+0.300	.001	.004	3	5
LUNG_NSCLC_LUAD	ARHGEF6 →	+1.069	+0.442	.007	<.001	3	4
BONE	THOC6 →	+0.825	+0.299	.003	.003	2	5
BLOOD_Lymphoma	POM121C →	+0.644	+0.225	.006	.006	3	4
BLOOD_Leukemia	BEND6 →	+1.168	+0.187	<.001	.003	3	3
BLOOD_Leukemia	TXNRD3 →	+1.326	+0.250	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018344 vs PHF3 — OVARY

Explore this scatter interactively →