Protein N-linked glycosylation via asparagine

pathway activity — cross-omics
GO:0018279Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Protein N-linked glycosylation via asparagine pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S120, RTN1, and CNRIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCTNS2_S120 →+0.487+0.054<.001<.00137
OVRTN1 →+0.390+0.043.003<.00136
BRCACNRIP1 →+0.500+0.038.001<.00136
LUADNUDT14 →+0.373+0.044<.001<.00136
HNSCEIF3G →-0.176-0.089<.001<.00127
CCRCCSYNPO →+0.305+0.031<.001.00236
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration