Protein N-linked glycosylation via asparagine

pathway activity — cross-omics
GO:0018279Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Protein N-linked glycosylation via asparagine pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD1, TSG101, and EPB41L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAKCTD1 →-0.523-0.222.001.00236
HNSCTSG101 →-0.825-0.180.005.00336
LSCCEPB41L1 →-0.671-0.145<.001<.00136
UCECVPS41 →-0.354-0.221.003.00736
CCRCCFKBP11 →+0.537+0.226<.001.00135
BRCAKIAA1109 →-0.589-0.241.006.00435
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration