Peptidyl-L-cysteine S-palmitoylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-L-cysteine S-palmitoylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARVCF_S343, CAMSAP3_S1020, and WDFY4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-L-cysteine S-palmitoylation activity versus ARVCF_S343 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARVCF_S343 →	+0.458	+0.044	.001	<.001	3	6
GBM	CAMSAP3_S1020 →	+0.765	+0.076	.003	<.001	3	5
LSCC	WDFY4 →	-0.504	-0.060	<.001	<.001	3	5
LUAD	ADAP2 →	-0.267	-0.037	<.001	.003	3	5
LSCC	CD14 →	-0.314	-0.041	<.001	.003	3	5
LSCC	FGD2 →	-0.295	-0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018230 vs ARVCF_S343 — UCEC

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