Peptidyl-L-cysteine S-palmitoylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-L-cysteine S-palmitoylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LUM, CLMP, and ASPN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-L-cysteine S-palmitoylation activity versus LUM in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LUM →	-0.767	-0.235	.009	.001	3	4
LSCC	CLMP →	-0.693	-0.206	<.001	<.001	3	4
UCEC	ASPN →	-0.934	-0.289	.001	.005	3	3
UCEC	SELENOI →	+0.483	+0.222	<.001	.005	3	3
UCEC	RNU6-647P →	+1.343	+0.226	.002	.005	2	4
UCEC	SNORD65C →	+1.402	+0.239	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018230 vs LUM — LSCC

Explore this scatter interactively →