Peptidyl-arginine methylation

pathway activity — cross-omics
GO:0018216Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Peptidyl-arginine methylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRMT6_T21, PSME3IP1, and TERF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCPRMT6_T21 →+0.767+0.070<.001<.00135
GBMPSME3IP1 →+0.319+0.054<.001<.00135
OVTERF2 →+0.310+0.033.004.00135
GBMSMC1A →+0.280+0.050<.001<.00135
HNSCDPH5 →+0.238+0.066.001.00335
UCECERH →+0.195+0.082.001.00935
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration