Peptidyl-arginine methylation

pathway activity — cross-omics
GO:0018216Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Peptidyl-arginine methylation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCER2, CAMK4, and ACTN4P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADFCER2 →-0.317-0.084<.001<.00133
LSCCCAMK4 →-0.380-0.143.006<.00133
LSCCACTN4P1 →+0.131+0.136.002.00333
COADTDRD10 →-0.207-0.141<.001.00333
UCECFAM207A →+0.647+0.129.009.00533
UCECTONSL →+0.544+0.106.002.00433
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration