Peptidyl-tyrosine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-tyrosine modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, HCLS1, and LCP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine modification activity versus TNS2_S102 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNS2_S102 →	+0.797	+0.045	<.001	<.001	3	10
GBM	HCLS1 →	+0.797	+0.063	<.001	<.001	3	10
GBM	LCP1 →	+0.872	+0.054	<.001	<.001	3	10
UCEC	PLEKHO2 →	+0.539	+0.054	<.001	<.001	3	10
LSCC	RASAL3_S72 →	+0.850	+0.054	<.001	<.001	3	10
GBM	RCSD1 →	+0.639	+0.054	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018212 vs TNS2_S102 — LSCC

Explore this scatter interactively →