Peptidyl-tyrosine modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-tyrosine modification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINB8, RAC3, and NT5E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERPINB8 grouped by Peptidyl-tyrosine modification-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SERPINB8 →	-1.392	-0.757	<.001	<.001	3	4
BONE	RAC3 →	+2.552	+0.526	.001	<.001	3	4
CNS	NT5E →	-2.418	-0.724	.006	.007	3	3
BREAST	FER →	-0.610	-0.541	.002	.005	3	3
BREAST	FBXO17 →	-2.509	-0.523	<.001	.009	3	3
CNS	PDCD5 →	-0.465	-0.694	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERPINB8 by Peptidyl-tyrosine modification activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →