Peptidyl-tyrosine modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-tyrosine modification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK3, PRKCD, and FGD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine modification activity versus RIPK3 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIPK3 →	+1.702	+0.916	.001	.003	3	4
BLOOD_Myeloma	PRKCD →	+1.085	+1.161	.006	.001	3	4
BREAST	FGD1 →	-0.923	-0.827	.004	.007	2	5
BREAST	KLHL7 →	-0.942	-1.012	<.001	<.001	3	4
BREAST	RDX →	-1.347	-0.829	<.001	.007	3	4
BLOOD_Myeloma	ZBED8 →	-0.698	-1.018	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018212 vs RIPK3 — BLOOD_Leukemia

Explore this scatter interactively →