Peptidyl-proline modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-proline modification pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are P4HA2, PLOD2, and CRTAP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline modification activity versus P4HA2 in BRCA (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	P4HA2 →	+0.598	+0.037	<.001	<.001	3	9
GBM	PLOD2 →	+0.923	+0.050	<.001	.002	3	8
BRCA	CRTAP →	+0.580	+0.039	<.001	<.001	3	7
CCRCC	GALNT2 →	+0.586	+0.045	<.001	<.001	3	7
BRCA	PLOD1 →	+0.630	+0.045	<.001	<.001	3	7
BRCA	VCL_S795 →	+0.477	+0.038	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018208 vs P4HA2 — BRCA

Explore this scatter interactively →