Peptidyl-proline modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-proline modification pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFOD1, PRPF31, and PSMD11, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline modification activity versus OGFOD1 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OGFOD1 →	+1.386	+0.130	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	PRPF31 →	+1.180	+0.111	<.001	.003	3	14
LIVER	PSMD11 →	+0.821	+0.109	.004	<.001	3	13
PANCREAS	C19orf12 →	+0.956	+0.136	<.001	<.001	3	13
BREAST	SAE1 →	+1.096	+0.115	<.001	<.001	3	13
BLOOD_Lymphoma	SRSF3 →	+0.911	+0.085	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018208 vs OGFOD1 — BLOOD_Lymphoma

Explore this scatter interactively →