Peptidyl-proline modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-proline modification pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK1, PSMB7, and PDLIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline modification activity versus CAMK1 in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CAMK1 →	+1.972	+0.110	<.001	.001	3	5
PANCREAS	PSMB7 →	-0.601	-0.164	.003	<.001	3	5
BONE	PDLIM1 →	-3.889	-0.208	.002	.002	3	5
BONE	NR3C1 →	-2.284	-0.234	.001	.003	3	5
BONE	BCL10 →	-1.294	-0.224	.003	.002	3	5
BONE	BCDIN3D →	+0.639	+0.186	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018208 vs CAMK1 — STOMACH

Explore this scatter interactively →