Peptidyl-proline modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-proline modification pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EBNA1BP2, NOP2, and PPP2R5D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-proline modification activity versus EBNA1BP2 in SOFT_TISSUE (Pearson r = -0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EBNA1BP2 →	-0.953	-0.148	.001	.008	2	8
PANCREAS	NOP2 →	-0.819	-0.171	<.001	<.001	3	7
LARGE_INTESTINE	PPP2R5D →	+0.860	+0.081	.002	.001	3	7
LUNG_SCLC	PIN1 →	+1.382	+0.179	<.001	<.001	3	7
OESOPHAGUS	WDR36 →	-0.826	-0.103	.002	.001	2	7
PANCREAS	NAT10 →	-0.940	-0.188	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018208 vs EBNA1BP2 — SOFT_TISSUE

Explore this scatter interactively →