Peptidyl-methionine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-methionine modification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPRC, SH3BP1, and VEZF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-methionine modification activity versus PTPRC in GBM (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPRC →	-0.560	-0.054	<.001	<.001	3	7
GBM	SH3BP1 →	-0.284	-0.060	<.001	<.001	3	7
GBM	VEZF1 →	+0.411	+0.074	.002	<.001	3	7
CCRCC	CYBB →	-0.592	-0.051	.001	<.001	3	7
HNSC	ISG20 →	-0.549	-0.061	<.001	.001	3	7
GBM	PARVG →	-0.526	-0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018206 vs PTPRC — GBM

Explore this scatter interactively →