Peptidyl-methionine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-methionine modification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAMDC2, MAOB, and LIFR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-methionine modification activity versus MAMDC2 in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAMDC2 →	-0.992	-0.139	.005	.002	3	4
BRCA	MAOB →	-1.580	-0.129	<.001	.009	3	4
UCEC	LIFR →	-0.859	-0.134	.001	.007	3	3
OV	ANKRD42 →	-0.499	-0.113	<.001	.003	3	3
OV	TXNDC11 →	-0.418	-0.140	.003	.002	3	3
OV	CHKB-DT →	-0.403	-0.120	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018206 vs MAMDC2 — UCEC

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