Peptidyl-methionine modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-methionine modification pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDF, THAP11, and EMC8, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-methionine modification activity versus PDF in BONE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PDF →	+1.353	+0.217	<.001	<.001	3	20
BONE	THAP11 →	+0.685	+0.159	<.001	<.001	3	17
BONE	EMC8 →	+0.774	+0.226	<.001	<.001	3	16
SOFT_TISSUE	DHX38 →	+0.776	+0.144	<.001	<.001	3	15
LUNG_NSCLC_LUAD	GFOD2 →	+0.893	+0.152	<.001	<.001	3	15
OVARY	DDX28 →	+0.794	+0.171	.001	.001	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018206 vs PDF — BONE

Explore this scatter interactively →