Peptidyl-lysine modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine modification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALKBH2, PDCD2L, and SNRNP70, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine modification activity versus ALKBH2 in KIDNEY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ALKBH2 →	+0.944	+0.254	.006	.006	3	5
LIVER	PDCD2L →	+0.967	+0.248	.005	.007	3	5
BLOOD_Myeloma	SNRNP70 →	+0.526	+0.258	.003	.007	3	5
BONE	TMEM70 →	+1.115	+0.422	.004	<.001	3	5
BONE	TTC7A →	-1.392	-0.312	.003	.005	3	4
OESOPHAGUS	EFEMP1 →	-4.164	-0.260	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018205 vs ALKBH2 — KIDNEY

Explore this scatter interactively →