Peptidyl-histidine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-histidine modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM98B, SPAG7, and CCDC12, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-histidine modification activity versus FAM98B in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM98B →	+0.292	+0.055	<.001	<.001	3	8
OV	SPAG7 →	+0.331	+0.028	<.001	<.001	3	7
PDAC	CCDC12 →	+0.489	+0.044	<.001	<.001	3	7
OV	GLOD4 →	+0.504	+0.034	.001	<.001	3	7
OV	METTL16 →	+0.300	+0.034	.003	<.001	3	7
HNSC	CASP10 →	-0.431	-0.047	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018202 vs FAM98B — LSCC

Explore this scatter interactively →