Peptidyl-histidine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-histidine modification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1-AS, APP, and RPS23P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-histidine modification activity versus TPM1-AS in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TPM1-AS →	-0.215	-0.332	.008	.003	3	4
CCRCC	APP →	-0.427	-0.755	<.001	<.001	3	3
BRCA	RPS23P2 →	+0.875	+0.457	<.001	.008	3	3
PDAC	ARPP19P1 →	+0.102	+0.515	.007	.007	3	3
HNSC	SETD7 →	-0.448	-0.311	.002	.007	3	3
HNSC	FARP1 →	-0.630	-0.299	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018202 vs TPM1-AS — LSCC

Explore this scatter interactively →