Peptidyl-histidine modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-histidine modification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOGARAM1, MLLT6, and MSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOGARAM1 grouped by Peptidyl-histidine modification-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TOGARAM1 →	-0.692	-1.398	<.001	.001	3	4
LUNG_NSCLC_LUAD	MLLT6 →	-0.929	-1.099	<.001	<.001	3	4
SKIN	MSL1 →	-0.590	-1.064	<.001	.002	3	4
BLOOD_Myeloma	MFAP3L →	-2.176	-1.553	.009	.003	3	4
LIVER	CAMKK2 →	-0.866	-2.027	<.001	.004	3	3
BLOOD_Myeloma	KCNK6 →	+2.350	+1.553	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOGARAM1 by Peptidyl-histidine modification activity — KIDNEY

Explore this box plot interactively →