Peptidyl-glutamic acid modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-glutamic acid modification pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A, ARL3, and HNF1B_S49, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-glutamic acid modification activity versus MAP1A in UCEC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP1A →	+0.512	+0.055	.005	.003	3	5
UCEC	ARL3 →	+0.317	+0.048	.002	.003	3	4
LSCC	HNF1B_S49 →	-0.947	-0.040	<.001	.002	3	4
CCRCC	CEP170 →	+0.210	+0.025	.003	.002	3	4
CCRCC	MAST3_S774 →	-0.383	-0.034	<.001	.001	3	4
LUAD	COL12A1 →	+0.616	+0.030	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018200 vs MAP1A — UCEC

Explore this scatter interactively →