Peptidyl-glutamic acid modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-glutamic acid modification pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC96, C21orf62-AS1, and POU6F2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-glutamic acid modification activity versus CCDC96 in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CCDC96 →	+0.293	+0.414	.001	.001	3	3
CCRCC	C21orf62-AS1 →	-0.307	-0.475	.002	.008	3	3
OV	POU6F2 →	+0.567	+0.563	.003	.006	3	3
OV	VDAC1P11 →	-0.206	-0.578	.004	.009	3	3
LUAD	E4F1 →	+0.333	+0.637	.001	<.001	3	3
LUAD	RPL8P1 →	-0.214	-0.563	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018200 vs CCDC96 — CCRCC

Explore this scatter interactively →