Peptidyl-glutamic acid modification

Across TCGA cell cohorts, RNA activity of the Peptidyl-glutamic acid modification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC9, HCFC2, and LRIT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-glutamic acid modification activity versus KLHDC9 in KIDNEY (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KLHDC9 →	-1.887	-0.261	.001	.003	3	4
OESOPHAGUS	HCFC2 →	+0.645	+0.361	.008	.009	3	3
KIDNEY	LRIT3 →	+0.162	+0.423	.008	<.001	3	3
KIDNEY	H1-0 →	-3.366	-0.403	<.001	.001	3	3
SKIN	TSC22D1 →	+1.526	+0.396	.003	.005	2	4
SKIN	CAPS →	+1.791	+0.442	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018200 vs KLHDC9 — KIDNEY

Explore this scatter interactively →