Peptidyl-cysteine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-cysteine modification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENPP5, RPRD2_S614, and RLIM_S164, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-cysteine modification activity versus ENPP5 in GBM (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ENPP5 →	+0.505	+0.059	<.001	<.001	3	5
LUAD	RPRD2_S614 →	+0.417	+0.030	<.001	.002	3	4
HNSC	RLIM_S164 →	-0.492	-0.070	.004	.002	3	4
PDAC	EPB41L2_S16 →	+0.572	+0.039	.008	<.001	3	4
GBM	PCLO_S906 →	+0.792	+0.053	<.001	<.001	3	4
LSCC	PPP1R12A_S995 →	-0.583	-0.026	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018198 vs ENPP5 — GBM

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