Peptidyl-cysteine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-cysteine modification pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPN, CSF3R, and SLC35B3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-cysteine modification activity versus ASPN in GBM (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ASPN →	-0.769	-0.800	<.001	<.001	3	3
LUAD	CSF3R →	+0.988	+0.219	<.001	.002	3	3
LSCC	SLC35B3 →	-0.316	-0.525	<.001	.003	3	3
GBM	OMD →	-0.687	-0.565	<.001	.006	3	3
LUAD	CEACAM3 →	+0.665	+0.239	<.001	<.001	3	3
PDAC	FPR2 →	+1.079	+0.496	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018198 vs ASPN — GBM

Explore this scatter interactively →