Peptidyl-arginine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-arginine modification pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZCCHC3, XRN2, and CRNKL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-arginine modification activity versus ZCCHC3 in COAD (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZCCHC3 →	+0.419	+0.034	<.001	<.001	3	6
COAD	XRN2 →	+0.232	+0.034	<.001	<.001	3	5
LSCC	CRNKL1 →	+0.383	+0.059	<.001	<.001	3	5
GBM	TAF4 →	+0.252	+0.032	.002	.009	3	5
LSCC	TOP2B →	+0.298	+0.060	<.001	<.001	3	5
LSCC	ADNP →	+0.259	+0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018195 vs ZCCHC3 — COAD

Explore this scatter interactively →