Protein oxidation

Across TCGA patient cohorts, RNA activity of the Protein oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, HTRA3, and LOX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein oxidation activity versus C1R in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1R →	+0.548	+0.078	<.001	<.001	3	9
CCRCC	HTRA3 →	+2.515	+0.106	.001	.009	3	9
GBM	LOX →	+0.980	+0.108	<.001	<.001	3	9
OV	THBS2 →	+1.448	+0.063	<.001	<.001	3	9
OV	CNN2 →	+0.810	+0.064	<.001	<.001	3	9
LSCC	COMP →	+1.218	+0.093	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018158 vs C1R — GBM

Explore this scatter interactively →