Protein oxidation

Across TCGA cell cohorts, RNA activity of the Protein oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMF1, LOXL2, and SYDE1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein oxidation activity versus SUMF1 in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SUMF1 →	+1.665	+1.282	<.001	<.001	3	16
LUNG_NSCLC_LUSC	LOXL2 →	+4.505	+0.867	<.001	<.001	3	15
LUNG_NSCLC_LUSC	SYDE1 →	+2.825	+0.850	<.001	<.001	3	13
BONE	NNMT →	+5.038	+1.194	<.001	<.001	3	13
LUNG_NSCLC_LUSC	LGALS1 →	+4.813	+0.866	<.001	<.001	3	12
BONE	LOX →	+4.332	+1.570	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018158 vs SUMF1 — LUNG_SCLC

Explore this scatter interactively →