Protein hydroxylation

Across TCGA cell cohorts, RNA activity of the Protein hydroxylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRLF3, TEX10, and FSD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein hydroxylation activity versus CRLF3 in BLOOD_Leukemia (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRLF3 →	-0.718	-0.238	.005	<.001	3	6
PANCREAS	TEX10 →	-1.127	-0.309	<.001	.001	3	5
LUNG_NSCLC_LUAD	FSD1 →	-1.678	-0.138	.002	.007	3	5
BLOOD_Leukemia	ZEB1 →	-1.491	-0.146	<.001	<.001	3	5
BLOOD_Myeloma	SCUBE2 →	+0.081	+0.136	.002	.003	3	5
PANCREAS	TCOF1 →	-0.998	-0.267	.003	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018126 vs CRLF3 — BLOOD_Leukemia

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