Protein polyglutamylation

Across TCGA patient cohorts, RNA activity of the Protein polyglutamylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARVCF, HSP90B1, and TRIM32, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polyglutamylation activity versus ARVCF in UCEC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARVCF →	+0.506	+0.073	<.001	<.001	3	4
OV	HSP90B1 →	-0.335	-0.041	<.001	<.001	3	4
BRCA	TRIM32 →	+0.167	+0.034	.006	.001	2	5
UCEC	INPP4A →	-0.292	-0.061	.003	.003	3	4
COAD	ATP13A1 →	-0.120	-0.028	.002	.003	3	4
OV	SCAF1_S929 →	-0.916	-0.058	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018095 vs ARVCF — UCEC

Explore this scatter interactively →