Protein polyglutamylation

Across TCGA cell cohorts, RNA activity of the Protein polyglutamylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ID2, ETV3, and MPV17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ID2 grouped by Protein polyglutamylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ID2 →	+2.152	+1.080	.003	.001	3	4
SKIN	ETV3 →	+0.880	+1.022	.008	.009	3	4
CNS	MPV17 →	+0.487	+0.848	.002	.005	3	4
CNS	WBP1 →	+0.702	+1.087	<.001	<.001	3	4
OESOPHAGUS	SDE2 →	+0.578	+1.087	.004	.008	3	3
LUNG_NSCLC_LUAD	ATP6V0B →	+0.545	+1.126	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ID2 by Protein polyglutamylation activity — BREAST

Explore this box plot interactively →