Peptidyl-lysine oxidation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine oxidation pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A1, NID2, and COL1A1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine oxidation activity versus COL5A1 in KICH (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	COL5A1 →	+2.451	+0.122	<.001	<.001	3	33
TGCT	NID2 →	+1.906	+0.103	<.001	<.001	3	33
DLBC	COL1A1 →	+2.818	+0.105	<.001	<.001	3	32
TGCT	LOX →	+2.191	+0.129	<.001	<.001	3	32
BLCA	PDGFRB →	+1.655	+0.085	<.001	<.001	3	32
GBM	LOXL1 →	+1.722	+0.134	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018057 vs COL5A1 — KICH

Explore this scatter interactively →