Peptidyl-lysine oxidation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine oxidation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, LOX, and IKBIP, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine oxidation activity versus LOXL2 in URINARY_TRACT (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LOXL2 →	+4.612	+1.528	<.001	<.001	3	18
BONE	LOX →	+4.332	+1.636	<.001	<.001	3	16
LUNG_NSCLC_LUSC	IKBIP →	+2.125	+1.423	<.001	<.001	3	16
LUNG_NSCLC_LUSC	VIM →	+6.111	+1.683	<.001	<.001	3	16
BONE	ACTN1 →	+2.045	+1.266	<.001	<.001	3	16
LUNG_NSCLC_LUSC	EMP3 →	+3.982	+1.403	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018057 vs LOXL2 — URINARY_TRACT

Explore this scatter interactively →