Peptidyl-lysine oxidation

Across TCGA cell cohorts, RNA activity of the Peptidyl-lysine oxidation pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Staurosporine, HG-5-113-01, and FS112, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Staurosporine grouped by Peptidyl-lysine oxidation-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Staurosporine →	-0.882	-1.360	.005	.026	3	1
CNS	HG-5-113-01 →	-0.466	-2.150	.005	<.001	3	1
CNS	FS112 →	-0.649	-1.603	.009	.019	3	1
CNS	Midostaurin →	-1.052	-1.575	.004	.021	3	1
CNS	AZD8186 →	-0.780	-1.706	.007	<.001	3	1
CNS	AT13148 →	-0.560	-1.472	.017	.026	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Staurosporine by Peptidyl-lysine oxidation activity — CNS

Explore this box plot interactively →