Peptidyl-lysine dimethylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine dimethylation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LTBP4, SMARCC2, and BRD3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine dimethylation activity versus LTBP4 in CCRCC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LTBP4 →	+0.600	+0.028	.002	.003	3	8
GBM	SMARCC2 →	+0.331	+0.051	<.001	.002	3	7
GBM	BRD3 →	+0.425	+0.063	<.001	<.001	3	7
GBM	SPEN_S1006 →	+0.378	+0.059	.003	<.001	3	6
GBM	SPIN1 →	+0.321	+0.051	<.001	<.001	3	6
GBM	TSHZ1_S671 →	+0.487	+0.057	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018027 vs LTBP4 — CCRCC

Explore this scatter interactively →