Peptidyl-lysine dimethylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine dimethylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1A, FCGR1B, and LINC02043, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine dimethylation activity versus FCGR1A in UCEC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCGR1A →	-0.802	-0.511	<.001	.008	3	4
GBM	FCGR1B →	-0.569	-0.338	<.001	.003	3	4
PDAC	LINC02043 →	+0.122	+0.231	.006	.002	3	3
LSCC	MTND4LP7 →	+0.357	+0.430	.004	.001	3	3
LSCC	ETV4 →	+0.943	+0.464	.003	.001	3	3
LSCC	TYMS →	+0.703	+0.492	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018027 vs FCGR1A — UCEC

Explore this scatter interactively →