Peptidyl-lysine monomethylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine monomethylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, LAS1L, and UBTF, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine monomethylation activity versus GATAD2B in HNSC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GATAD2B →	+0.336	+0.061	<.001	<.001	3	7
LSCC	LAS1L →	+0.316	+0.056	<.001	<.001	3	7
LSCC	UBTF →	+0.263	+0.046	<.001	.004	3	7
HNSC	DIDO1 →	+0.320	+0.046	<.001	<.001	3	7
HNSC	RBBP5 →	+0.240	+0.065	<.001	<.001	3	7
GBM	ILF3 →	+0.148	+0.028	.004	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018026 vs GATAD2B — HNSC

Explore this scatter interactively →